TITLE:
Study of Lipocalin-2 Associated with Neutrophilic Gelatinases (uNGAL) in the Urine in Children with the Microbial Inflammatory Diseases of Kidneys and Urinary Tract
AUTHORS:
E. D. Bondarenko, A. V. Eremeeva, V. V. Dlin, A. A. Korsunsky, S. B. Orekhova, S. Gurbanova
KEYWORDS:
Lipocalin-2, Associated with Neutrophilic Gelatinases (NGAL), Acute Pyelonephritis, Urinary Tract Infection, Children
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.3 No.12,
December
18,
2015
ABSTRACT: Purpose of the study: Research of the
clinical and diagnostic significance of determination of Lipocalin-2 associated
with neutrophilic gelatinases (uNGAL) in the urine of children with urinary
tract infection (UTI) and pyelonephritis. Materials and methods: We examined 30
children with acute pyelonephritis and UTI aged 1 to 16 years (average age 7.32
± 4.52) including 26 girls and 4 boys. Verification of the diagnosis was
conducted on the basis of clinical and laboratory data, medical history and
instrumental examination of patients. All children were divided into 2 groups:
1st group—15 children with acute pyelonephritis, 2nd group—15
children with urinary tract infection. uNGAL was measured in the urine by
enzyme-linked immunosorbent assay (EISA) (BioVendor Laboratoty Medicine). Results:
It is found, that the urine level of NGAL depends on the damage degree of renal
parenchyma. The correlation of medium strength was found between the excretion
level of uNGAL during the acute period of pyelonephritis and the detection of
renal scars according to the DMSA-nephroscintigraphy data. In the group of
children with the acute pyelonephritis the direct correlation of medium
strength was found between the excretion level of uNGAL/creatinine and
leukocytosis value and also with the CRP blood level. Conclusion: The results
allow us to recommend the determination of the excretion level of
uNGAL/creatinine as an additional non-invasive marker for the early detection
of renal parenchyma injury.