TITLE:
Oncofertility in Gynecologic Malignant Tumors
AUTHORS:
Masataka Adachi, Kouji Banno, Iori Kisu, Megumi Yanokura, Moito Iijima, Takashi Takeda, Kiyoko Umene, Yuya Nogami, Eiichiro Tominaga, Daisuke Aoki
KEYWORDS:
Gynecological Cancer, Fertility Preservation, Cryopreservation, Uterine Transplantation, Pregnancy
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.14,
December
8,
2015
ABSTRACT: Long-term survival is the priority in
treatment of patients with malignant tumors. In the field of gynecology,
fertility preservation has also recently become an important objective due to improved
treatment outcomes and different needs of patients. Methods for fertility
preservation include cervical conization, ovarian protection against radiation
or chemotherapy for ovarian cancer since the ovary is hypersensitive to cancer
therapies, treatment of gynecological cancer during pregnancy, and
cryopreservation of oocytes, embryos or ovarian tissue before treatment of malignant
tumors. Radical trachelectomy for early cervical cancer and treatment with
medroxy progesterone acetate for early endometrial carcinoma are also options
for fertility preservation, but the efficacy and risk of recurrence have yet to
be fully evaluated. The first childbirth following uterine transplantation was
also achieved last year and this success has expanded the potential for
pregnancy and delivery among cancer survivors.