TITLE:
Cerebral Microbleeds Identified by Susceptibility-Weighted Imaging in Two Cases of Fabry Disease without Neurological Symptoms
AUTHORS:
Mineka Yamazoe, Masayuki Maeda, Maki Umino, Hidekazu Tomimoto, Hajime Sakuma
KEYWORDS:
Fabry Disease, Magnetic Resonance Imaging, Susceptibility-Weighted Imaging, Cerebral Microbleeds
JOURNAL NAME:
Open Journal of Medical Imaging,
Vol.5 No.4,
December
4,
2015
ABSTRACT: Cerebrovascular disease is one of the fatal causes of Fabry disease (FD). Brain magnetic resonance imaging findings typically show lacunar infarcts in young patients with FD, but brain hemorrhages in FD are rarely reported. We report two cases of FD focusing on cerebral microbleeds (CMBs). Susceptibility-weighted imaging (SWI) and T2*-weighted imaging reveal several lobar and deep CMBs in two patients with no medical history of stroke symptoms, hypertension, and anticoagulant/antiplatelet treatment. SWI can detect a greater number of CMBs than T2*-weighted imaging. Thus, SWI is an excellent tool for identifying underlying CMBs in FD.