TITLE:
Efficacy of 5-Fluorouracil and High-Concentration Cisplatin Suspended in Lipiodol by Short-Term Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis
AUTHORS:
Yutaka Yata, Masashi Namikawa, Tatsuya Ohyama, Takashi Ohsaki, Daisuke Kanda, Takeshi Hatanaka, Kei Shibuya, Jun Kubota, Hitoshi Takagi, Terumi Takahara, Teruo Yoshinaga
KEYWORDS:
Advanced Hepatocellular Carcinoma (HCC), Portal Vein Tumor Thrombosis (PVTT), Hepatic Arterial Infusion Chemotherapy (HAIC), 5-FU, a Fine-Powder Formulation of Cisplatin, Quality of Life (QOL), Cost-Effective Treatment
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.13,
December
3,
2015
ABSTRACT: Background: Since advanced hepatocellular carcinoma (HCC) is potentially
fatal, and patients’ quality of life (QOL) often deteriorates during their
treatment, improving the prognosis and QOL of patients given chemotherapy is
very important. In addition, cost-effective treatments are highly desirable
when chemotherapy must be given repeatedly. The aim of this study was to
evaluate the efficacy and usefulness of 5-fluorouracil (5-FU) and
high-concentration cisplatin by short-term hepatic arterial infusion
chemotherapy (3-day FPL) in advanced HCC patients. Methods: Thirty patients
with unresectable advanced HCC were enrolled. The patients underwent hepatic
arterial infusion chemotherapy via the implanted port system with 5-FU on days
1 - 3 and a fine-powder formulation of cisplatin in suspended pre-warmed
lipiodol on day 2 every 4 to 10 weeks. Tumor response was assessed one month
later with CT. Results: All patients had evidence of portal vein invasion
(Vp2-4). Four patients achieved a complete response (CR), 8 patients achieved a
partial response (PR), and 7 patients had stable disease (SD). The median
progression-free survival (PFS) and overall survival (OS) were 198 days and 452
days, respectively. The OS was significantly longer in the successful disease
control group (CR, PR, and SD) than in the progressive disease group (P