TITLE:
Evaluation of the Results of Radical Management of a Cohort of 107 Patients with Hepatocellular Carcinoma in Colombia
AUTHORS:
Sergio Hoyos, Jaime Chávez, Álvaro Duarte, Isabel Arenas
KEYWORDS:
Liver Cancer, Cirrhosis, Liver Transplant
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.13,
December
3,
2015
ABSTRACT: Introduction: Hepatocellular carcinoma (HCC) is the most common primary
tumor of the liver and usually appears as part of liver cirrhosis (LC). Its
management in the presence of LC is ideally with orthotopic liver
transplantation. Surgical resection is indicated only in the presence of a
tumor in a patient with a very good liver function and who for medical reasons
cannot be carried to transplantation. Materials and Methods: A descriptive
study of a prospective and consecutive series of patients undergoing surgery
(resection or liver transplantation) for HCC in a hospital in the city of
Medellin was performed, from June 2004 to January 2015. A multivariate analysis
was carried out of factors associated with survival during the follow-up.
Results: 116 surgical interventions for the management of HCC between June 2004
and January 2015 were performed. The analysis included 107 patients, of which
73% were men. The median age of all patients was 60 years. The factors that
showed better survival were: patients undergoing transplantation, the presence
of cirrhosis, tumor less than 5 cm in diameter, a unique and
well-differentiated tumor; however, none of these factors achieved statistical
significance. Conclusion: Both resection and liver transplantation, when well
indicated achieve good 5-years of survival in patients with HCC.