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Fotsis, T., Pepper, M.S., Aktas, E., Breit, S., Rasku, S., Adlercreutz, H., W?h?l?, K., Montesano, R. and Schweigerer, L. (1997) Flavonoids, Dietary Derived Inhibitors of Cell Proliferation and in Vitro Angiogenesis. Cancer Research, 57, 2916-2921.

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• TITLE: Isoflavone Ameliorates H2O2 Induced Injury by Activating the Antioxidant System of Sow Mammary Gland Cell

  AUTHORS: Xianyong Ma, Zongyong Jiang, Jian Zhang, Youjun Hu, Kaiguo Gao, Li Wang, Xuefen Yang

  KEYWORDS: Isoflavone, Antioxidant System, Sow Mammary Gland Cell

  JOURNAL NAME: Natural Science, Vol.7 No.12, November 25, 2015

  ABSTRACT: The antioxidant and protective properties of a synthetic soybean isoflavone (ISO) were investigated using sow mammary gland cell. Cells were cultured with 10, 20 and 30 uM ISO, respectively, under 80 uM FeSO4·7H2O/H2O2 conditions. After 48 h of incubation, the cells in the presence of ISO were lost less compared with that of control under oxidative damage by H2O2/FeSO4; ISO decreased the cell number at G1 and G2 stages, increased the cell number at S stage (all P P P P P rd to 6th days. Upon these, the activities of total superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant ability (T-AOC) also were increased and the activities of NADPH oxidase (NOX) decreased by ISO treatment (all P P P P P P P P P P P