TITLE:
Evaluation of BMI and Lipids Profile in Type 2 Diabetic Subjects with Low and Raised Levels of Thyroid Hormone in Calabar, Nigeria
AUTHORS:
C. E. J. Udiong, M. H. Etukudoh, I. K. Isong, E. F. Udoisa
KEYWORDS:
Diabetes, Hypothyroid, Hyperthyroid, Lipids, BMI
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.5 No.4,
November
5,
2015
ABSTRACT: Relationship between lipid levels and BMI was investigated in euthyroid,
hyperthyroid, hypothyroid, general Type 2 diabetics, and non-diabetic control
subjects. FT4, T4, T3 and TSH did not differ
in obese and non-obese diabetics but were higher in diabetics than in non-diabetics
(p = 0.015, 0.012, 0.0164
respectively). Levels of FT4 correlated with TC, LDL-C, VLDL-C, TG
and HDL-C (r = 0.179, p = 0.034; r =
0.183, p = 0.033; r = 0.183 p = 0,033; r = 0.176, p = 0.037; r = -0.210, p = 0.023 respectively). T3 levels
correlated with TC (r = 0.210: p =
0.023), LDL-C (r = 0.193: p = 0.025),
and VLDL-C (r = 0.244: p = 0.003)
levels in diabetic subjects. FT4 and T4 levels correlated
with BMI only in the non-diabetic subjects (p = 0.022, 0.025) respectively. TC and LDL-C levels correlated positively with
BMI in non-diabetics (r = 0.265, p =
0.006; r = 0.249, p = 0.010), general
diabetics (r = 0.247, p = 0.016; r =
0.291, p = 0.002), euthyroid (r =
0.274, p =0.017; r = 0.252, p = 0.022) and hyperthyroid (r = 0295, p = 0.008; r = 0.346, p = 0.002) diabetics respectively. There
were negative correlations between BMI and HDL-C in the diabetics (r = -0.188, p = 0.018) and euthyroid (r = -0.273, p =0.018) groups. Atherogenic index
correlated negatively with BMI in all 5 groups of subjects. The coexistence of
both low and raised levels of thyroid hormones in the diabetic population
altered the levels and interrelationship between lipids and BMI. Altered levels
of FT4 observed in Type 2 diabetics emanated from diabetes not
obesity. Atherogenic index is an efficient indicator of atherogenic risk
irrespective of complications.