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Choi, J.I., Raghavendran, H.R.B., Sung, N.Y., Kim, J.H., Chun, B.S., Ahn, D.H., Choi, H.S., Kang, K.W. and Lee, J.W. (2010) Effect of Fucoidan on Aspirin-Induced Stomach Ulceration in Rats. Chemico-Biological Interactions, 183, 249-254.
http://dx.doi.org/10.1016/j.cbi.2009.09.015

has been cited by the following article:

• TITLE: Effect of Fucoidan Dietary Supplement on the Chemotherapy Treatment of Patients with Unresectable Advanced Gastric Cancer

  AUTHORS: Masahide Ikeguchi, Hiroaki Saito, Yasunari Miki, Takayuki Kimura

  KEYWORDS: Chemotherapy, Fucoidan, Gastric Cancer, Toxicity, Prognosis

  JOURNAL NAME: Journal of Cancer Therapy, Vol.6 No.11, October 30, 2015

  ABSTRACT: In Japan, S-1 plus cisplatin has become a standard regimen for the treatment of unresectable advanced gastric cancer; however, many patients are unable to continue effective chemotherapy because of the regimen’s severe side effects. Thus, control of drug toxicity is key to prolonging patient survival. Fucoidan is a major sulfated polysaccharide found in brown seaweeds and has a wide range of biological activities. In the present study, we analyzed the effect of fucoidan on suppressing the toxicity of chemotherapy drugs. Twenty-four patients with unresectable advanced gastric cancer underwent treatment with S-1 plus cisplatin and were randomly allocated into a fucoidan treatment group (n = 12) or a control group without fucoidan treatment (n = 12). The study results demonstrated that fucoidan controlled the occurrence of fatigue during chemotherapy and patients could continue chemotherapy for longer time periods by maintaining the patients’ favorable nourishment status. As a result, the survival of patients with fucoidan treatment was longer than that of patients without fucoidan. Thus, fucoidan should be included as a key food supplement for patients with gastrointestinal carcinomas who are suffering from the adverse side effects of chemotherapy.