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Therasse, P., Arbuck, S.G., Eisenhauer, E., Wanders, J., Kaplan, R.S., Rubinstein, L., Verweij, J., van Glabbeke, M., van Oosterom, A.T., Christian, M.C. and Gwyther, S.G. (2000) New Guidelines to Evaluate the Response to Treatment in Solid Tumors. Journal of the National Cancer Institute, 92, 205-216.
http://dx.doi.org/10.1093/jnci/92.3.205
has been cited by the following article:
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TITLE:
Effect of Fucoidan Dietary Supplement on the Chemotherapy Treatment of Patients with Unresectable Advanced Gastric Cancer
AUTHORS:
Masahide Ikeguchi, Hiroaki Saito, Yasunari Miki, Takayuki Kimura
KEYWORDS:
Chemotherapy, Fucoidan, Gastric Cancer, Toxicity, Prognosis
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.11,
October
30,
2015
ABSTRACT: In Japan, S-1 plus cisplatin has become a standard regimen for the
treatment of unresectable advanced gastric cancer; however, many patients are
unable to continue effective chemotherapy because of the regimen’s severe side
effects. Thus, control of drug toxicity is key to prolonging patient survival.
Fucoidan is a major sulfated polysaccharide found in brown seaweeds and has a
wide range of biological activities. In the present study, we analyzed the
effect of fucoidan on suppressing the toxicity of chemotherapy drugs.
Twenty-four patients with unresectable advanced gastric cancer underwent
treatment with S-1 plus cisplatin and were randomly allocated into a fucoidan
treatment group (n = 12) or a control group without fucoidan treatment (n =
12). The study results demonstrated that fucoidan controlled the occurrence of
fatigue during chemotherapy and patients could continue chemotherapy for longer
time periods by maintaining the patients’ favorable nourishment status. As a
result, the survival of patients with fucoidan treatment was longer than that
of patients without fucoidan. Thus, fucoidan should be included as a key food
supplement for patients with gastrointestinal carcinomas who are suffering from
the adverse side effects of chemotherapy.