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Kirchner, H., Hofmann, S.M., Fischer-Rosinsky, A., Hembree, J., Abplanalp, W., Ottaway, N., et al. (2012) Caloric Restriction Chronically Impairs Metabolic Programming in Mice. Diabetes, 61, 2734-2742.
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TITLE:
Hysteresis of White Adipose Tissue
AUTHORS:
Alain Géloën, Hédi Soula, Lilas Hadji, Emmanuelle Berger
KEYWORDS:
Adipocyte Size, White Adipose Tissue, Calorie Restriction, Hysteresis
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.5 No.10,
October
28,
2015
ABSTRACT: Objective: This study was
performed to analyze the modifications within adipose tissue during calorie
restriction and more specifically to state whether hysteresis occurs during fat
mass reduction. Method: Rats male Wistar increased their body weight by 130 g
under control conditions and were then submitted to a calorie restriction (CR)
at 30% or 60% of control. Experiment has been stopped when the body weight of
the group CR60% returned back to its initial value. Samples of retroperitoneal
adipose tissue were collected by biopsies along the study. Adipose cell size
was analyzed using multisizer IV (Beckman Coulter) to determine the size
distribution curves during natural growth and after calorie restriction.
Results: After CR60%, body weights and adipose tissue masses were similar to
the ones at the beginning of the experiment. Adipose cell size distribution
curve was shifted to the left compared to the one of initial control. Adipose
cell sizes were significantly lower after CR60% than those of control at the
beginning of the experiment. Conclusions: These results state for the first
time that hysteresis occurs in white adipose tissue after calorie restriction.
The composition of adipose tissue after calorie restriction was significantly
different than the one of initial control. After significant weight loss,
organisms must be considered as different from the initial controls, they are
most likely governed by different regulations which will have to be identified.