TITLE:
Delivery Outcome in Women with Major Sickle Cell Syndrome: A Comparative Study of the Homozygous Forms “SS” versus the Heterozygous “SC”
AUTHORS:
Amah Biova Adama-Hondégla, Abdoul-Samadou Aboubakari, Kossi Edem Logbo-Akey, Kodjo Fiagnon, Akila Bassowa, Koffi Akpadza
KEYWORDS:
Sickle Cell Disease, Childbirth, Prognosis, Homozygous SS, Heterozygous SC, Togo, Africa
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.5 No.12,
October
28,
2015
ABSTRACT: Objectives: To determine the prevalence of women who
delivered in the two major sickle cell syndromes, “SS” and “SC”, and to identify maternal and early neonatal
prognosis inherent to each form. Material and Methods: This is a comparative,
descriptive and retrospective cross-sectional study of 226 files of women
carrying major sickle cell syndrome (66 cases of “SS” form versus 160 cases of
“SC” form), collected from May 2008 to May 2013 at the Gynecology and
Obstetrics Clinic of the Sylvanus Olympio’s University Hospital of Lomé. Data
were processed by Epi Info 6 software. For comparison of variables, the Chi-2
test of Fisher with significance as p major sickle cell
syndromes represent 0.8% of all the deliveries during the study period. Caesarean
section, especially prophylactic one, was the dominant mode of delivery. The SS
forms have been exposed to have more vaso-occlusive crises (22.7% vs. 13.1%; p
= 0.04, OR = 0.31), more blood transfusion (57.6% vs. 29.4%; p = 7 × 10-5,
OR = 3.2) and more puerperal infections (p gave exposure to greater maternal morbidity.
Resuscitative measures in adults and newborns should be reinforced at
the delivery time of these “at-risk-pregnancies”.