TITLE:
Bronchoscopic Diagnosis of Solitary Pulmonary Nodules with the Use of NIR Spectroscopy
AUTHORS:
Votruba Jiri, Brůha Tomas, Balaz Teodor
KEYWORDS:
Solitary Pulmonary Nodule, Near Infrared Spectroscopy, Endobronchial Ultrasound, Fluoroscopy, Biopsy
JOURNAL NAME:
Advances in Chemical Engineering and Science,
Vol.5 No.4,
October
22,
2015
ABSTRACT: Background: Recently, SPN has become a much more frequently encountered issue in bronchology. Efficient and reliable guidance method for SPN morphological proof is highly needed. Objectives: The aim of study was to compare the diagnostic values of NIR (near infrared) spectroscopy with EBUS for SPN diagnostic. Fluoroscopic guidance with TBB and needle biopsy were done in all patients. Methods: In our study, we used two types of monitoring systems. Fluoroscopic guidance was combined with either a radial EBUS or a NIR spectroscopy probe for tissue confirmation. 139 male and 71 female patients, having a medial age of 68 years with CT/PET findings of metabolically active SPN were examined between 2/2010 and 2/2013. We designed an instrument for measurement of the penetration of the NIR through lung tissue. Indicating and source fibers were navigated towards the SPN. An EBUS radial probe was used, during fluoroscopic navigation. Results: The statistical analysis of the results obtained showed a comparative specificity and sensitivity of the NIR spectroscopy, with radial EBUS. Conclusions: NIR spectroscopy produced similar efficacies as the radial EBUS. However, the number of positive biopsies was more dependent upon the ability to direct the confirmatory device to the SPN during fluoroscopic guidance than on the type of the device.