TITLE:
Lack of Association between Polymorphisms in rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 Sites of FGFR2 Gene with Breast Cancer in the Population of Kazakhstan
AUTHORS:
Timur S. Balmukhanov, Alexandra K. Khanseitova, Victoria G. Nigmatova, Alena S. Neupokoeva, Daria A. Sharafutdinova, Nagima A. Aitkhozhina
KEYWORDS:
Fibroblast Growth Factor Receptor 2 (FGFR2), Single Nucleotide Polymorphism (SNP), Association, Breast Cancer (BC), Kazakhstan
JOURNAL NAME:
Advances in Breast Cancer Research,
Vol.4 No.4,
October
20,
2015
ABSTRACT: Worldwide, breast cancer (BC) is the most common invasive cancer in
women. Fibroblast growth factor receptor 2 (FGFR2) is a tyrosine kinase
receptor that is a member of the family of individually distinct fibroblast
growth factor receptors involved in tumorigenesis. FGFR2 gene is amplified and over expressed in breast cancer (1 - 3).
The aim of the study was to determine whether polymorphisms in rs2981582,
rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 in FGFR2 gene are associated with breast
cancer susceptibility in the population of Kazakhstan. The statistically
significant associations between SNPs analyzed and breast cancer risk according χ2 and p FGFR2 with BC risk in the world populations could not be unambiguously
used for Kazakhstan population.