TITLE:
A Retrospective Study of Clinicoepidemiological Aspects of Nasopharyngeal Cancer at NCI-Cairo (2000-2010)
AUTHORS:
Hebatallah K. Ibrahim, Tarek Shouman, Azza Niazy Taher, Azza M. Nasr, Hesham Atef
KEYWORDS:
Nasopharyngeal Cancer, Radiotherapy
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.11,
October
14,
2015
ABSTRACT: Aim of Work: The aim of this work was to study the clinico-epidemiological
characteristics of the patients with nasopharyngeal carcinoma (NPC), analyse the prognostic factors of the disease and to analyse the
results of different treatment modalities and their effect on loco-regional, distal
metastatic disease control and both overall survival (OS) and disease free survival
(DFS) rates. Patients and Methods: This is a retrospective study reviewing all adult
nasopharyngeal carcinoma (NPC) patients who presented to the radiotherapy department—National
Cancer Institute Cairo University in the period from (2000-2010). Results: In this
study, it was found that the mean age was 45 years; most of the patients were of
locally advanced stages. Multivariate cox proportional hazards regression identified
T-stage, radiotherapy course completion & addition of chemotherapy as independent
prognostic factors for local control (LC), DFS, & OS. The 5-year LC, DFS and
OS rates for all studied patients were 38.2%, 33.5% & 37.2% respectively. The
median DFS was 26 months and median OS was 36.5 months. Conclusion: This study matches
the published data that support that radical concurrent chemoradiation is the mainstay
of treatment of locally advanced NPC, & that T-stage, M-stage, prescribed dose
completion, response to initial treatment are independent prognostic factors for
survival. All measures should be taken to improve the local response during primary
treatment as this will improve survival rates of patients with NPC.