TITLE:
Solventless Organic Reactive Crystallization at Mild Conditions
AUTHORS:
Masaaki Yokota, Norihito Doki, Hiroyuki Akagaki
KEYWORDS:
Reaction, Crystallization, Polymorphism, Dehydration Condensation
JOURNAL NAME:
Advances in Chemical Engineering and Science,
Vol.5 No.4,
October
12,
2015
ABSTRACT: Solid state mixtures of two reactants, 2-hydroxy-1-naphthaldehyde and 2-aminobenzonitrile, were melted at a temperature even lower than both the melting points. And dehydration condensation reaction occurred in the melt to give reaction product N-(2-cyanophenyl)-2-hydroxy-1-naphthadimine. Since the melting point of the product was higher than the reactants, self-crystallization of the product occurred. Usefulness of this one-pot synthesis and crystallization method for industrial application was described.