Article citationsMore>>

Schuller, J., Cassidy, J., Dumont, E., Roos, B., Durston, S., Banken, L., Utoh, M., Mori, K., Weidekamm, E. and Reigner, B. (2000) Preferential Activation of Capecitabine in Tumor Following Oral Administration to Colorectal Cancer Patients. Cancer Chemotherapy and Pharmacology, 45, 291-297.
http://dx.doi.org/10.1007/s002800050043

has been cited by the following article:

• TITLE: Intravenous Fluorouracil versus Oral Capecitabine: Postoperative Chemoradiation for Gastric Cancer

  AUTHORS: H. Abbas, Shimaa Ahmed, Ahmed A. S. Salem, Mohamed Abou Elmagd Salem, Mahmoud Hussin, Wessam A. El Sherief

  KEYWORDS: Fluorouracil, Capecitabine, Chemoradiation, Postoporative, Gastric Cancer

  JOURNAL NAME: Journal of Cancer Therapy, Vol.6 No.11, October 8, 2015

  ABSTRACT: Purpose: Aim of this prospective, phase III trial was to compare the efficacy and toxicity of intravenous fluorouracil and oral capecitabine when given concurrently with radiation in adjuvant sitting for adenocarcinoma of the stomach after gastrectomy with D2 resection. Patients and Method: The study included 60 patients having histologically proven adenocarcinoma of the stomach or gastroesophageal junction; stage T2-4 N0-3 M0 after gastrectomy with D2 lymph node dissection. Eligible patients were randomly assigned to receive adjuvant radiotherapy concurrently with intravenous fluorouracil [arm A] or oral capecitabine [arm B]. Results: Ten patients cannot complete their whole treatment course because of either progressive [4 patients; 2 arm A and 2 arm B] or G 3 toxicity [1 patient] or refuse to complete their treatment [5 patients; 3 arm A and 2 arm B]. Patients received fluorouracil have significant increase grade 3 or 4 hematological [neutropenia] and gastrointestinal (diarrhoea, anorexia, and vomiting). During a median follow-up period of 24 months, the 2-year disease free and overall survivals in this study were 60% and 63.3%, for groups A and B respectively, while overall survival were 63.3% and 70% for groups A and B respectively without significant differences. Conclusion: Oral capecitabine concurrently with radiation therapy has comparable efficacy and favourable toxicity profile when compared to infusion fluorouracil as postoperative adjuvant therapy for gastric adenocarcinoma.