TITLE:
Exploration and Research on HIV/AIDS Patients’ Complement C1q Level Changes before and after Treatments
AUTHORS:
Guosheng Su, Xiaolu Luo, Shunda Luo, Zeduan Liu, Zuyan Ni, Wanhong Huang, Juanying Liang
KEYWORDS:
HIV, AIDS, Complement C1q, Immune Transmission Turbidity
JOURNAL NAME:
Advances in Infectious Diseases,
Vol.5 No.3,
September
24,
2015
ABSTRACT: Objective: The study aimed
to investigate the complement C1q test results of HIV/AIDS patients in clinical
application before and after treatments. Methods: We collected HIV/AIDS
patients’ serum specimens storing at -80 centigrade freezer in cryogenic
refrigerator for standby. After samples quantity met the requirements of
selected cases unified, complement C1q was detected by immune transmission turbidity
method, and compared the differences in complement C1q of HIV/AIDS patients in
test results before and after treatment. In the collection of 96 cases selected
samples, concentration of complement C1q was 157.95 ± 31.46 mg/L before
treatment, while after treatment, it was 147.26 ± 28.76 mg/L. Comparing the
results before and after treatment,t= 2.45726,P= 0.01049, the difference was
statistically significant. Concentration of complement C1q increased after
treatment with 33 cases. There were 63 cases reducing. Through statistical
analysis on the data from the number of reducing and increasing cases,
chi-square = 18.75,P= 0.00356, the difference was
statistically significant. Complement C1q detection in the treatment of
patients with HIV/AIDS had an important clinical significance in the process.
The analysis of the concentration changes before and after treatment was
clinically significant for drug selection and monitoring disease progression
and curative effects, which would be worth further researching.