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Arii, K., Ota, K., Suehiro, T., Ikeda, Y., Nishimura, K., Kumon, Y. and Hashimoto, K. (2005) Pioglitazone Prevents Reactive Hypoglycemia in Impaired Glucose Tolerance. Diabetes Research and Clinical Practice, 69, 305-308. http://dx.doi.org/10.1016/j.diabres.2005.01.004

has been cited by the following article:

• TITLE: Idiopathic Reactive Hypoglycemia: Mechanisms of Onset and Remission with High Protein Low Carbohydrate Diet

  AUTHORS: Keshavan Prakash, Mary Kabadi, Udaya M. Kabadi

  KEYWORDS: Idiopathic Reactive Hypoglycemia, High Protein, Low Carbohydrate Diet

  JOURNAL NAME: Open Journal of Endocrine and Metabolic Diseases, Vol.5 No.9, September 23, 2015

  ABSTRACT: Objective: Idiopathic reactive hypoglycemia is defined as early postprandial hypoglycemia occurring on ingestion of high carbohydrate containing meal. Remission ensues with high protein low carbohydrate diet. This study assessed roles of insulin and glucagon in its onset and remission. Methods: Plasma glucose, insulin and glucagon were determined after an overnight fast and repeatedly until 180 minutes on ingestion of 3 meals; 100 g glucose; 100 g pure protein liquid and mixture of 50 g each at 14 days’ interval. Five adults with IRH and 6 age matched healthy volunteers participated. Results: In IRH, glucose ingestion induced prompt rise in glucose (5.1 ± 0.8 to10.5 ± 1.2 mM/L) followed later by hypoglycemia (2.6 ± 0.4 mM/L). Insulin rose from 7 ± 2 to 90 ± 18 mU/L. Glucagon rose initially (10% ± 2%) from elevated basal concentration (373 ± 57 mU/L) followed by later decline (-43% ± 12%). On protein ingestion, glucose declined followed by a restoration to basal level while both insulin and glucagon rose (28 ± 6 mU/L; 148% ± 38%, p