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Trachootham, D., Alexandre, J. and Huang, P. (2009) Targeting Cancer Cells by ROS-Mediated Mechanisms: A Radical Therapeutic Approach? Nature Reviews Drug Discovery, 8, 579-591.
http://dx.doi.org/10.1038/nrd2803

has been cited by the following article:

• TITLE: Oxidative Stress Induced by CuO Nanoparticles (CuO NPs) to Human Hepatocarcinoma (HepG2) Cells

  AUTHORS: Xin Fu

  KEYWORDS: CuO NPs, ROS, Cell Viability

  JOURNAL NAME: Journal of Cancer Therapy, Vol.6 No.10, September 21, 2015

  ABSTRACT: The toxicity of CuO nanoparticles (CuO NPs) to human hepatocarcinoma (HepG2) cells was investigated in this study. CuO NPs (1 - 40 mg/L) had significant toxicity to HepG2 cells. The antioxidant N-acetyl-L-cysteine (NAC) significantly reduces the cytotoxicity induced by the CuO NPs, supporting the hypothesis that oxidative stress contributes to the cytotoxicity of CuO NPs. To further explore the oxidative mechanisms of cytotoxicity, we examined CuO NPs-induced production of reactive oxygen species (ROS) in HepG2 cells. CuO NPs generated intracellular ROS in HepG2 cells in a concentration-dependent manner.