TITLE:
Oxidative Stress Induced by CuO Nanoparticles (CuO NPs) to Human Hepatocarcinoma (HepG2) Cells
AUTHORS:
Xin Fu
KEYWORDS:
CuO NPs, ROS, Cell Viability
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.10,
September
21,
2015
ABSTRACT: The toxicity of CuO nanoparticles (CuO NPs) to human hepatocarcinoma
(HepG2) cells was investigated in this study. CuO NPs (1 - 40 mg/L) had
significant toxicity to HepG2 cells. The antioxidant N-acetyl-L-cysteine (NAC)
significantly reduces the cytotoxicity induced by the CuO NPs, supporting the
hypothesis that oxidative stress contributes to the cytotoxicity of CuO NPs. To
further explore the oxidative mechanisms of cytotoxicity, we examined CuO
NPs-induced production of reactive oxygen species (ROS) in HepG2 cells. CuO NPs
generated intracellular ROS in HepG2 cells in a concentration-dependent manner.