TITLE:
Effect of Soy Bean Isoflavon on Lipid Accumulation in 3T3-L1 Adipocytes
AUTHORS:
Teruhiko Matsushima, Noriko Yoshimura, Yuumi Koseki
KEYWORDS:
Obesity, Adipocyte, Genistein, Resveratrol
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.3 No.9,
September
17,
2015
ABSTRACT: Several nutrition and food
ingredients are supposed to have beneficial effects, but precise cell biological
mechanism has not been elucidated. Among food ingredients, polyphenols such as
soy bean isoflavon genistein and wine resveratrol have been reported to have
effects on lipid metabolism and cardiovacular diseases (1). In order to elucidate
the effect of genistein on obesity, we cultured adipocyte and observed of
genisten to lipid accumulation in cells. Triglyceride accumulation was
suppressed by genistein when it was added at the time of differentiation but
not when added after differentiation. Genistein is considered to suppress lipid
accumulation by suppressing the differtiation of adipocytes.