TITLE:
Clinical Characteristics of Invasive Methicillin-Resistant Staphylococcus aureus at General Hospital in the Central Region of Japan from July 2014 to June 2015
AUTHORS:
Masaaki Minami, Ryoko Sakakibara, Taichi Imura, Hideo Morita, Naoto Kanemaki, Michio Ohta
KEYWORDS:
Methicillin-Resistant Staphylococcus aureus, Susceptibility, Antimicrobial Resistance, Invasive Disease
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.3 No.9,
September
17,
2015
ABSTRACT: Methicillin-resistant Staphylococcus aureus
is crucial pathogen caused severe invasive infection disease. This study was
conducted to find out the prevalence and antimicrobial susceptibility pattern
of invasive Methicillin-resistant Staphylococcus aureus isolates at general
hospital in the central region of Japan from July 2014 to June 2015. Methicillin-resistant
Staphylococcus aureus was identified by standard laboratory procedure.
Antimicrobial susceptibility testing was performed by micro dilution assay
according to CLSI recommendation. Invasive Methicillin-resistant Staphylococcus
aureus disease was defined as isolation of bacteria from a normally sterile
body site. One hundred seventy-one methicillin-resistant Staphylococcus aureus were
isolated among which 95 (55.6%) were from inpatient and 76 (44.4%) were from
outpatient. The age incidence of (0 - 1) years, (1 - 10) years, (11 - 40)
years, (41 - 60) years and >60 years age groups were 18 (10.5%), 41 (24.0%),
15 (8.8%), 5 (2.9%), and 92 (53.8%) respectively. There was significant difference
of age distribution between invasive and noninvasive disease in 0 - 1 years
group and 11 - 40 years age group. Positive samples were received mostly from
the pediatrics (56/32.7%), respiratory medicine (25/14.6%) and general medicine
(25/14.6%). We also found the significant differences of department between
invasive and noninvasive disease in pediatrics, dermatology, and surgery.
Arbekacin, teicoplanin, and vancomycin were the most active antibiotics with
100% susceptible rates in our study. Our study revealed that erythromycin and
gentamicin were more antimicrobial effective in invasive disease than in
noninvasive disease significantly. Methicillin-resistant Staphylococcus aureus infection
spreads worldwide easily and inadequate use of antibiotics contributes to
uptake of their new antimicrobial resistance. Continuous antimicrobial surveys
are need for guiding policy on the adequate use of antibiotics to reduce the
morbidity and mortality.