TITLE:
A Comparative Study of Topical Azailic Acid Cream 20% and Active Lotion Containing Triethyl Citrate and Ethyl Linoleate in the Treatment of Mild to Moderate Acne Vulgaris
AUTHORS:
Hayder R. Al-Hamamy, Adil A. Noaimi, Ihsan A. Al-Turfy, Adil Ibrahim Rajab
KEYWORDS:
Acne Vulgaris, Inflammatory, Aknicare, Azelaic Acid
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.5 No.3,
September
10,
2015
ABSTRACT: Background: Acne vulgaris is a common disorder affecting 79% - 95% of the
adolescent population. The choice of treatment depends on the severity, patients
with mild to moderate acne should receive topical therapy such as azelaic acid.
Rising antibiotic drug resistance consequent to the widespread use of topical
antibiotics is causing concern and effective non-antibiotic treatments are
needed. Objective: To compare
the efficacy and side effects of topical azelaic acid cream 20% versus active
lotion containing triethyl citrate and ethyl linoleate (TCEL) in treatment of
mild to moderate acne vulgaris. Patients
and Methods: This single, blinded, comparative, therapeutic study was
done in the Department of Dermatology-Baghdad Teaching Hospital, Baghdad, Iraq;
from May 2013-July 2014. Scoring of acne was carried out and the patients were
examined every 2 weeks for 10 weeks of treatment. One month after stopping
drugs, patients were evaluated for drug complications and disease recurrence. Sixty
patients fulfilling enrollment criteria were included in this study. Patients
were divided into 2 groups: Group A (30 patients) treated twice daily
with TCEL lotion and Group B (30 patients) treated twice daily with
topical azelaic acid cream 20%. Results:
Both topical TCEL lotion and azelaic acid cream were statistically an effective
therapy for treatment of mild to moderate acne vulgaris. TCEL lotion was more
effective and act earlier than azelaic acid
cream starting from 4 weeks of therapy till the end of treatment (after 10
weeks) and even after 4 weeks after stopping the treatment (P-value non-inflammatory acne lesions. Its
use would reduce the risk of antibiotic resistance developing within the skin
flora.