TITLE:
Synthesis of New Fluorinated 1,2,4-Triazino [3,4-b][1,3,4]thiadiazolones as Antiviral Probes-Part II-Reactivities of Fluorinated 3-Aminophenyl-1,2,4-triazinothiadiazolone
AUTHORS:
Mohammed Saleh Tawfek Makki, Reda Mohammady Abdel Rahman, Ola Ahmad Abu Ali
KEYWORDS:
Synthesis, Fluorinated 1, 2, 4-Triazinothiadiazolones, Anthelmintic Drugs
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.5 No.3,
September
8,
2015
ABSTRACT: Some new fluorinated 3-N-acyl/3-N-alkylaminophenyl-1,2,4-triazino[3,4-b][1,3,4]thiadiazolones (2-12) have been obtained from treatment of 2-(4'-fluorophenyl)-6-(2'-amino-5'-fluorophenyl)-1,2,4-triazino[3,4-b][1,3,4]thiadiazol-4-one(1) with active functional oxygen, sulfur and halogen compounds in different conditions. Former structures of the products have been characterized from elemental and spectral data (UV, IR, NMR and Mass). The new products were evaluated as potential anthelmintic drugs.