Article citationsMore>>

Moore, S., Patel, R.P., Atherton, E., Kondo, M., Meienhofer, J. (1976) Synthesis and Some Properties and Antitumor Effects of the Actinomycin Lactam Analog, (Di(1-L-Alpha, Beta-Diaminopropionic))Actinomycin D1. Journal of Medicinal Chemistry, 19, 766-772.
http://dx.doi.org/10.1021/jm00228a006

has been cited by the following article:

• TITLE: Cancer Therapy Using Antibiotics

  AUTHORS: Biplob Bhattacharya, Sreya Mukherjee

  KEYWORDS: Antibiotics, Lactams, Cancer, Mechanism of Action

  JOURNAL NAME: Journal of Cancer Therapy, Vol.6 No.10, September 4, 2015

  ABSTRACT: Anticancer antibiotics have made a successful impact in the field of chemotherapeutics. For most of them, DNA is the molecular target. Some act as DNA intercalators or some prevent DNA repair among other mechanisms of actions, they are seen to have. The major disadvantages of these drugs though are the constant side effects and toxicities. With more focus on discovery of new drugs with newer scaffolds, the urge to discover and modify anticancer antibiotics is being lost. Modifications or even the wider research can yield newer better drugs for clinical use. The review here discusses the current antibiotic therapeutics, newer discoveries in the field as well ideas for future research.