TITLE:
Aspect of QOL Assessment and Proposed New Scale for Evaluation
AUTHORS:
Nobuo Yamaguchi, Matsuo Arai, Tsugiya Murayama
KEYWORDS:
QOL, Leukocyte Subset, Granulocyte, Lymphocyte, Constitution Dependent Assay System, Double Blind-Cross Over System, Immunological Factors, Emotional Hormone, Adrenalin, Dopamine, Anti-Oxidative Assay by Macrophage, Immunological Factors
JOURNAL NAME:
Open Journal of Immunology,
Vol.5 No.3,
August
31,
2015
ABSTRACT: According to the reports from Ministry of Health in each country, the average life span is elongated over the past decade. This trend is expected to be keeping constant further in the future and at the same time continued efforts should be made. Next, it is necessary for us to consent about improving the quality of life. In an effort of improving the quality of life, other than the western medicine, we have attempted to introduce many traditional medical practices, including the oriental medicine, from various parts of the world into the medical field as a complementary & alternative medicine (CAM). Judging both positive and negative aspects by the evaluation standard of the Western medicine, we try to obtain numerical aspects in termed of QOL. Some methods of alternative medicine involved in this review are acupuncture, moxibustion, TCM and other traditional medicine. Above all, WHO suggests selecting the suzerain nation of acupuncture moxibustion, which has been developed in the oriental countries as a specialized cure, by identifying merits & demerits and ascertaining which nation can be a the best model for special field. At the moment for evaluating CAM, for example, what kind of methods is/are suitable for evaluating each CAM. We have been trying to propose the peripheral leukocyte, that is one of the best marker for evaluating CAM. Our trial is a hot spring hydrotherapy, acupuncture and moxibution, light exercise and Ondle/floor heating etc. In these trials, we find the common results from leukocyte effects which exhibit a strong correlation for the regulation in number and function, as a new scale for evaluating QOL. The contents are the result from the data showing the much in number of volunteer tend to down regulate, on the other hand, lower number of volunteer is up-regulated at next day by each menu of CAM as a constitution dependent manner. However, even in western medical methodology, double blind and cross over system are the better way to evaluation even in CAM. The responsibility in human to each CAM therapy is different in individually, so to say according to constitution. In other words, there are so many vectors within the group, including at least three groups, up-regulating, down regulating and stand stilled one. So we have no positive results by the method by sum-up and made mean. According to this system, individual vector is cancelled each other and real effect is not exhibited as a final result. So, we would like to present more smart way to access the efficacy for CAM menu. That is trial to plot each individual effect on the linear function and making slant/co-efficiency that plot each variable vector which is derived from the relative value compared to that of the day before. This procedure is easy to compare between each impact to the volunteer. We would like to propose this evaluation system as Super Constitution System: SCS. This kind of regulation showed within a 24 hours, for the leukocyte subsets, granulocyte and lymphocyte are changed even if they are under control of the circadian rhythm. So, for the purpose of evaluating leukocyte deviation, we set the point for evaluation at the same time-zone from the first set of evaluation to the next time-zone of evaluation. Under these conditions, we get a same result reproductively that the whole number of leukocyte, and its subset, granulocyte and lymphocyte also regulate within a 24 hours. This kind of phenomenon is the case that we confirm a lot of kind of CAM with repetition. This kind of regulation is confirmed in the content of the emotional hormone regulation. Within a hormonal change, adrenalin and dopamine are just under the regulation in the mode of SCS. However, the life span of leukocyte are at lease 3 - 4 days in rapid group of leukocytes, and no such a drastic apoptosis is induced by such a stimulation. For the purpose of scientific explanation, we also propose that the emotional hormone is concerned this change of leukocytes population. For the results of this hypothesis, there are reasonable changes in the peripheral blood about emotional hormone, adrenaline and dopamine. Other hormone concern thyroid grand is not changed significantly. In the final part of this chapter, we also propose that the suitable approach for anti-oxidative assessment and the effective pathway of complement for enabling some historical food supplement activate the whole body cell that expresses a complement receptor. This is not a case of infection but another stage of complement activation by fragmented polysaccharides for historical human use as foods. The protein materials are also fermented and served as digestive food around the world. Almost all the products have some distinctive smell but accompanying some effects through independent digestive rout for intact protein itself. With these aspects, we try to emphasize SCS and discuss by showing evident based manner with various menu of CAM.