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Zhu, S., Wang, Y., Chen, M., Jin, J., Qiu, Y., Huang, M. and Huang, Z. (2012) Protective Effect of Schisandrin B against Cyclosporine A-Induced Nephrotoxicity in Vitro and in Vivo. The American Journal of Chinese Medicine, 40, 551-566.
http://dx.doi.org/10.1142/S0192415X12500425

has been cited by the following article:

• TITLE: Investigation of in Vitro and in Vivo Metabolism of Schisandrin B from Schisandrae Fructus by Liquid Chromatography Coupled Electrospray Ionization Tandem Mass Spectrometry

  AUTHORS: Tianxiu Qian, Pou Kuan Leong, Kam Ming Ko, Wan Chan

  KEYWORDS: Schisandrin B, Metabolism, Disposition, UPLC-MS/MS

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.6 No.8, August 24, 2015

  ABSTRACT: Schisandrin B (Sch B) is one of the active dibenzocyclooctadiene lignans found in the Schisandrae Fructus. Experimental studies have shown that Sch B possesses various pharmacological properties, including anti-cancer, neuroprotective and nephroprotective activities. However, no detailed information on its biotransformation was reported in the literature. Here, we investigated the in vitro and in vivo metabolism of Sch B by using ultra-performance liquid chromatography coupled with tandem mass spectrometry. In vitro study detected and identified one oxygenated metabolite. Four metabolites were detected and identified from the in vivo study. The results indicated that the metabolism of Sch B mainly involved the demethylation of methoxy groups, the opening of five-member ring and the glucuronidation of metabolites in rats. The metabolites were identified for the first time by MS/MS analyses.