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Higgs, J., Wasowski, C., Loscalzo, L.M., et al. (2013) In Vitro Binding Affinities of a Series of Flavonoids for μ-Opi-oid Receptors. Antinociceptive Effect of the Synthetic Flavonoid 3, 3-Dibromoflavanone in Mice. Neuropharmacology, 72, 9-19.
http://dx.doi.org/10.1016/j.neuropharm.2013.04.020

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• TITLE: Peripheral Analgesic and Anti-Inflammatory Effects of Smilax canariensis in an Animal Model

  AUTHORS: Sandra Dévora, Susana Abdala, Domingo Martín-Herrera

  KEYWORDS: Smilax canariensis, Smilacaceae, Medicinal Plant, Folk Medicine, Analgesic Activity, Anti-Inflammatory Activity

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.6 No.8, August 24, 2015

  ABSTRACT: Smilax canariensis Brouss. ex Willd. is an endemic plant of the Canary Islands. Its rhizomes, leaves and stems have been traditionally used in Canary folk medicine to treat a wide variety of conditions including pain. Our objective is to investigate the analgesic and anti-inflammatory activities of different extracts of S. canariensis in Swiss mice, using established biological models for pain and inflammation, such as phenylquinone writhing test, formalin test, tail-flick test and mouse paw edema induced by carrageenan. Oral administration of S. canariensis extracts significantly reduce writhing episodes evoked by phenylquinone injection in a dose-dependent manner; and higher doses result in a reduction of pain similar to or higher than that of the reference drug piroxicam (59.56%; p