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Schaefer, H. and Schoenfelder, P. (2009) Smilax canariensis, S. azorica (Smilacaceae) and the Genus Smilax in Europe. In: Beltrán Tejera, E., Afonso-Carrillo, J., García Gallo, A. and Rodríguez Delgado, O., Eds., Homenaje al Profesor Dr. Wolfredo Wildpret de la Torre, Instituto de Estudios Canarios, La Laguna (Tenerife. Islas Canarias), Monografía LXX-VIII, 297-306.

has been cited by the following article:

• TITLE: Peripheral Analgesic and Anti-Inflammatory Effects of Smilax canariensis in an Animal Model

  AUTHORS: Sandra Dévora, Susana Abdala, Domingo Martín-Herrera

  KEYWORDS: Smilax canariensis, Smilacaceae, Medicinal Plant, Folk Medicine, Analgesic Activity, Anti-Inflammatory Activity

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.6 No.8, August 24, 2015

  ABSTRACT: Smilax canariensis Brouss. ex Willd. is an endemic plant of the Canary Islands. Its rhizomes, leaves and stems have been traditionally used in Canary folk medicine to treat a wide variety of conditions including pain. Our objective is to investigate the analgesic and anti-inflammatory activities of different extracts of S. canariensis in Swiss mice, using established biological models for pain and inflammation, such as phenylquinone writhing test, formalin test, tail-flick test and mouse paw edema induced by carrageenan. Oral administration of S. canariensis extracts significantly reduce writhing episodes evoked by phenylquinone injection in a dose-dependent manner; and higher doses result in a reduction of pain similar to or higher than that of the reference drug piroxicam (59.56%; p