TITLE:
The Differences of Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) Levels between Asphyxiated and Non-Asphyxiated Neonates
AUTHORS:
Nur Dian Firmani, Tetty Yuniati, Dedi Rachmadi
KEYWORDS:
Neutrophil Gelatinase-Associated Lipocalin, Asphyxia, Neonates
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.5 No.3,
August
21,
2015
ABSTRACT: Objective: To evaluate the differences of urinary NGAL levels between
asphyxiated and non-as- phyxiated neonates. Methods: This was a cross-sectional observational
analytic study, including 34 newborns in Dr. Hasan Sadikin Hospital, Bandung,
Indonesia. Sample collection was conducted from December 2014 to March 2015.
Urine NGAL levels were evaluated using enzyme-linked immunosorbent assays
(ELISA) technique. To determine the differences of urinary NGAL levels between
asphyxiated and non-asphyxiated group we used Mann-Whitney U test, and to
determine the differences of gestational age and birth weight between these two
groups we used Fisher’s exact test. Results: Twenty males (60%) and 14 females
(40%) neonates participated in the study. From 34 subjects, 17 neonates were
diagnosed with asphyxia and 17 neonates without asphyxia. The results showed
that urine NGAL levels had significantly increased in asphyxiated neonates. The
median urine NGAL level in asphyxiated group is 95% CI: 506.7 (60.0 - 651.7)
ng/mL, while the median urine NGAL level in non-asphyxiated group is 95% CI:
6.7 (0.1 - 53.0) ng/mL. Statistically, there were significant urine NGAL levels
differences between asphyxiated and non-asphyxi- ated neonates (p 0.05).
Conclusions: Urinary NGAL levels in asphyxiated neonates were significantly
higher than those in non-asphyxiated neonates. There were significant
differences of urine NGAL levels between the groups.