TITLE:
Hyponeurotrophinemia in Serum of Women with Polycystic Ovary Syndrome as a Low Grade Chronic Inflammation
AUTHORS:
Farideh Zafari Zangeneh, Maryam Bagheri, Mohammad Mehdi Naghizadeh
KEYWORDS:
Polycystic Ovary Syndrome (PCOS), Nerve Growth Factor α (NGF α), Sympathetic Nervous System (SNS), Interleukin 1α, 1β, 17A, TNFα
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.5 No.9,
August
21,
2015
ABSTRACT: Introduction: This study aimed to discuss about
neuroimmune-pathophysiology of polycystic ovary syndrome (PCOS). Nerve growth
factor (NGF) as modulator of neuro-endocrine-immune (NEI) system plays a
critical role in tissue survival and homeostasis maintenance. It is a strong
marker for sympathetic nerve activity. Women with PCO have enhanced ovarian NGF
production. Over the past few decades, PCOS has been discussed as a low grade
chronic inflammatory disease. In this study, we investigated the neuromodulator
role of serum NGF and inflammatory cytokines (IL-1α, β, 17A and TNF-α) in women with PCOS. Material and
Methods: 171 patients were investigated in two groups: study (n = 85 PCO)
and control (n = 86). Serum levels of NGF-α and interleukins IL-1α, IL-1β, IL-17A and TNFα were determined in both groups by ELISA kit. Results: Data of
this study showed that the level of NGF-α and IL-17A in serum of PCO women were lower than control group (p α, IL-1β were higher than control group in PCO women (p α, IL-1β. Reduction of
IL-17A and NGF in serum of PCO patients might be under the direct influence of
the hyperactivity of sympathetic nervous system (SNS).