TITLE:
Determination of the Compound Biological Effectiveness (CBE) Factors Based on the ISHIYAMA-IMAHORI Deterministic Parsing Model with the Dynamic PET Technique
AUTHORS:
Shintaro Ishiyama, Yoshio Imahori, Jun Itami, Hanna Koivunoro
KEYWORDS:
Boron Neutron Capture Therapy, Compound Biological Effectiveness, Borono-Phenyl-Alanine, Tumor, 10B(n, α)7Li, Sigmoid Function
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.8,
August
19,
2015
ABSTRACT: Purpose: In defining the biological effects of the 10B(n, α)7Li
neutron capture reaction, we have proposed a deterministic parsing model (ISHIYAMA-IMAHORI model) to determine the Compound Biological Effectiveness (CBE) factor in Borono-Phenyl-Alanine (BPA)-mediated
Boron Neutron Capture Therapy (BNCT).
In present paper, we demonstrate a specific method of how the application of
the case of application to actual patient data, which is founded on this model for tissues and tumor. Method: To determine the CBE factor, we derived the
following new calculation formula founded on the deterministic parsing model
with three constants, CBE0, F, n and the eigen value Nth/Nmax.
(1), where, Nth and Nmax are the threshold value of boron concentration of N and saturation boron density and CBE0, F and n are given as 0.5,
8 and 3, respectively. In order to determine Nth and Nmax in the formula, sigmoid
logistic function was employed for 10B concentration data, Db(t) obtained by dynamic PET technique. (2), where, A, a and t0 are
constants. Results and Conclusion: From
the application of sigmoid function to dynamic PET data, it is concluded that
the Nth and Nmax for tissue and tumor
are identified with the parameter constants in the sigmoid function in Equation
(2) as: (3). And the calculated CBE factor values obtained from Equation (1), with Nth/Nmax.