TITLE:
Expression of Multidrug Resistance ATP-Binding Cassette (ABC) Transporters in Canine Mammary Tumors
AUTHORS:
Breno S. Salgado, Suely Nonogaki, Luisa M. Soares, Angela Akamatsu, Cristiano R. N. da Silva, Thiago P. Anacleto, Rodolfo Malagó, Rafael M. Rocha, Fátima Gärtner, Noeme S. Rocha
KEYWORDS:
MDR1, P-Gp, MRP1, MRP2, ABCC2, Mammary Neoplasms, Prognosis, Dog
JOURNAL NAME:
Advances in Breast Cancer Research,
Vol.4 No.3,
July
29,
2015
ABSTRACT: Mammary neoplasms are the most common tumors in female dogs. They are
usually treated using solely surgical mastectomy—which is recognized as
unsatisfactory in many cases. Given this, the benefits of chemotherapy in dogs
with mammary cancer need to be further explored. Some drugs that can be used
for treating canines with mammary tumors may be substrates of uptake and/or
efflux transporters such as the ATP-binding cassette (ABC) transporters.
Unfortunately, very little is known regarding the pathobiology of such proteins
in canine tumors, including mammary cancer. Accordingly, this study was
designed to characterize the expression of ABC transporters P-glycoprotein,
MRP1, and MRP2 and their relation with clinicopathologic factors in order to
allow a better understanding of their influence in canine mammary cancer.
P-glycoprotein was expressed in tumors from 55.8% of patients, while MRP1 and
MRP2 were expressed in 37.2% and 39.5% of tumors, respectively. P-glycoprotein
expression showed to be related with regional lymph node spread (P = 0.0038), as
well as with tumor grade (P = 0.0353) and with a shorter survival (P = 0.0245).
MRP1 revealed a strong association with a higher histological grade (P