TITLE:
ADRB2, ADRB3, BDKRB2 and MTNR1B Genes Related to Body fat Modulation and Its Interaction with Physical Activity and Blood Pressure
AUTHORS:
Aline Marcadenti
KEYWORDS:
Receptors, Adrenergic, Beta-2; Receptor, Bradykinin B, Obesity, Hypertension
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.5 No.7,
July
29,
2015
ABSTRACT: Hypertension (HTN) is the
risk factor that most contributes to mortality rates in the world, followed by
physical inactivity and obesity. Despite the influence of genetic factors on
the genesis of HTN, blood pressure levels are strongly influenced by
environmental factors such as physical inactivity and overweight,
characterizing it as a polygenic disease. Genetic components and environmental
factors such as physical exercise may modulate the phenotype of individuals
predisposed to medical conditions such as HTN, independently of modifiable
factors such as increased levels of adiposity; however, studies have shown that
polymorphic forms detected in genes involved in the mechanisms of blood
pressure regulation and also related to body fat modulation may interact with
physical activity levels and HTN. The aim of this article is to review the
interactions between polymorphisms in ADRB2, ADRB3, BDKRB2 and MTNR1B genes, physical activity and blood
pressure.