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Nakayama, M., Takahashi, K., Komaru, T., Fukuchi, M., Shioiri, H., Sato, K., Kitamuro, T., Shirato, K., Yamaguchi, T., Suematsu, M. and Shibahara, S. (2001) Increased Expression of Heme Oxygenase-1 and Bilirubin Accumulation in Foam Cells of Rabbit Atherosclerotic Lesions. Arteriosclerosis, Thrombosis, and Vascular Biology, 21, 1373-1377.
http://dx.doi.org/10.1161/hq0801.093592

has been cited by the following article:

• TITLE: Protective and Indicating Effect of Indirect Bilirubin in Intracranial or Extracranial Artery Atherosclerotic Stenosis Progresses

  AUTHORS: Yingzhu Chen, Xianxian Zhang, Lingling Zhang, Rongyin Qin, Kangping Song, Lu Xiao

  KEYWORDS: Indirect Bilirubin, Atherosclerotic Stenosis, Intracranial Arteries, Extracranial Arteries

  JOURNAL NAME: International Journal of Clinical Medicine, Vol.6 No.7, July 23, 2015

  ABSTRACT: Background: Bilirubin is the metabolic end-product of heme degradation by heme oxy-genase (HO), which has recently been shown to act as an antioxidant which can protect against atherosclerosis. This study explored the relationship between serum bilirubin levels and different degrees of atherosclerotic stenosis in intracranial or extracranial arteries. Methods: The study included 189 patients undergoing digital subtraction angiography (DSA) diagnosed as being normal or having been confirmed as atherosc lerotic stenosis in the intracranial or extracranial arteries. The patients were allocated to normal, mild (Results: Indirect bilirubin (Ibil) concentrations increased in parallel with the increasing severity of atherosclerotic stenosis in the intracranial or extracranial arteries, but decreased in patients with occluded cranial vessels. Multivariate analysis showed that Ibil levels were significantly higher in patients with severe stenosis group than in those with mild stenosis (OR, 1.464; 95% CI, 1.050 - 2.042; P = 0.024). However, Ibil levels were significantly lower in patients with occlusion than in those with severe stenosis (OR, 0.790; 95% CI, 0.684 - 0.913; P = 0.001). Conclusions: Ibil appears to have a protective effect against the development of atherosclerotic stenosis in intracranial or extracranial arteries. The biosynthesis of Ibil increases with stenosis progresses but decreases once occlusion occurs.