TITLE:
One-Pot Three Component Domino Reaction for the Synthesis of Novel Isoxazolo[2,3-c][1,3,5]Thiadiazepin-2-Ones Catalyzed by PTSA—A Green Chemistry Approach
AUTHORS:
Eligeti Rajanarendar, Paka Venkateshwarlu, Saini Rama Krishna, Kundur Govardhan Reddy, Kammari Thirupathaiah
KEYWORDS:
Multi-Component Green Synthesis, Isoxazolo[2, 3-c][1, 3, 5]Thiadiazepin-2-Ones, PTSA
JOURNAL NAME:
Green and Sustainable Chemistry,
Vol.5 No.3,
July
21,
2015
ABSTRACT: The synthesis of novel isoxazolo[2,3-c][1,3,5]thiadiazepin-2-ones has been achieved in excellent yields by one-pot three-component Domino reaction without the production of toxic waste products by using p-toluene sulfonic acid (PTSA) as a Lewis acid catalyst. PTSA plays a crucial role in the success of the reaction, as well as for increasing reaction rate.