Article citationsMore>>

Sledge, J., Graham, W.A., Westmoreland, S., Sejdic, E., Miller, A., Hoggatt, A. and Nesathurai, S. (2013) Spinal Cord Injury Models in Non Human Primates: Are Lesions Created by Sharp Instruments Relevant to Human Injuries? Medical Hypotheses, 81, 747-748.
http://dx.doi.org/10.1016/j.mehy.2013.07.040

has been cited by the following article:

• TITLE: Humane Non-Human Primate Model of Traumatic Spinal Cord Injury: Quantitative Analysis of Electromyographic Data

  AUTHORS: Nitin Seth, Farah Masood, John B. Sledge, William A. Graham, Douglas L. Rosene, Susan Westmoreland, Shiela Macri, Ervin Sejdic, Amber Hoggatt, Heather Simmons, Hussein A. Abdullah, Shanker Nesathurai

  KEYWORDS: Spinal Cord Injury, Animal Model, Electromyography

  JOURNAL NAME: Open Journal of Veterinary Medicine, Vol.5 No.7, July 20, 2015

  ABSTRACT: A valid non human primate model of traumatic spinal cord injury (TSCI) is essential to evaluate and develop new treatments. In previous experiments, it has been demonstrated that a transmitter can be implanted in the macaque fasicularis monkey that measures electromyographic data from the musculature of the tail. As well, previous experiments have demonstrated that selective lesions can be created in the lower thoracic spinal cord that does not cause limb weakness and/or bowel dysfunction. The histopathological features of these lesions appear similar to human TSCI. This paper describes a method by which the EMG data can be transformed into a quantitative metric of volitional limb movement (“Q”). This metric permits an objective assessment of injury, natural recovery as well as potential efficacy of candidate treatments.