TITLE:
The Anti-Proliferative Effect of 5-Fluorouracil on Tumor Is Highly Associated with the Renewal of Peripheral White Blood Cells
AUTHORS:
Xiuping Qian, Xiaolei Qian, Xinlin Chen, Mei Ge, Daijie Chen, Wenwei Mao
KEYWORDS:
5-Fluorouracil, Chemotherapy, Renewal, White Blood Cells, Bone Marrow Regeneration
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.7,
July
16,
2015
ABSTRACT: The efficacy of
chemotherapy is thought to be direct killing of tumor cells, but documented
studies have been shown that immunity plays a role in its effectiveness. In a
pilot study to observe the bone marrow suppression and regeneration in tumor
bearing mice induced by single dose injection of 5-fluorouracil (5-FU), we
unexpectedly found that tumors grew fast as bone marrow mononuclear cells (BMC)
and peripheral white blood cells (PWBC) were decreased quickly during
myelosuppression meanwhile significantly slow as repopulating of BMC and PWBC
during bone marrow regeneration after 5-FU treatment, no matter whether in low
or high dose administration, but the higher the dose was, the lower of the
nadir of BMC and PWBC were reached to, as well as the much more powerful
duration and strength of the repopulated BMC and PWBC, suggested that the
immunity might be a predominant drive in 5-FU chemotherapy. Due to the fact
that BMC is the source of PWBC which is its final maturational and functional
form, it could be proposed that the anti-proliferative effect of 5-FU on tumor
is highly associated with the renewal of PWBC.