TITLE:
Enhancement of Sister Chromatid Exchanges (SCEs) in Peripheral Blood Lymphocytes of Women with Polycystic Ovary Syndrome (PCOS) in Vitro
AUTHORS:
Evagelia Dafa, Maria Kontou, Tzegiaver B. Mantratzi, Emmanouel N. Kontomanolis, Nikoletta G. Koutlaki, Vasilios A. Liberis, Theodore S. Lialiaris
KEYWORDS:
Polycystic Ovary Syndrome, Proliferative Rate Index, Mitotic Index, Genotoxicity, Cytostaticity
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.5 No.7,
July
15,
2015
ABSTRACT: The aim of the present study was to determine the level of underlying DNA
damage in females with PCOS. Twenty-two women with PCOS and twenty-two healthy
controls were included in this study. Patients were further categorized into
three phenotypic subgroups: Subgroup A,
oligo/anovulation (ANOV) and polycystic ovaries (PCO); Subgroup B, hyperandrogenism (HA) as a main characteristic (HA + ANOV
or HA + PCO); Subgroup C, all three
conditions present (HA + ANOV + PCO). The frequency of sister chromatid
exchanges (SCEs) was used as an index of cytogenetic damage. Proliferation rate index (PRI), mitotic index (MI),
average generation time (AGT) and population doubling time (PDT) were
also evaluated. A significant (p