TITLE:
The Level of Soluble FMS-Like Tyrosinkinase-1, Placental Growth Factor and Vitamin E in Pre-Eclampsia and Normotensive Pregnancy
AUTHORS:
John Wantania, Meilany Durry, Janno Bernadus
KEYWORDS:
sFlt-1, PlGF, Vitamin E, Pre-Eclampsia, Normotensive Pregnancies
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.6 No.7,
July
10,
2015
ABSTRACT: Background: This study aims to determine the differences of angiogenic markers sFlt-1 (soluble FMS-like tyrosine kinase-1), Placental Growth Factor (PlGF) and antioxidant (vitamin E) levels in pre-eclampsia compared with normotensive pregnancies. Methods: In a cross-sectional study performed on 40 normotensive pregnancies and 40 pre-eclampsia women, serum levels of sFlt-1, PlGF and vitamin E were measured with ELISA methods. Statistical analysis used Mann Whitney. Results: The serum levels from the group of normotensive pregnancy and pre-eclampsia women consecutively are as follows: sFlt-1 2251.32 ± 416.17 pg/mL and 2950.78 ± 221.34 pg/mL, having a very significant difference (p = 0.00); PlGF 391.67 ± 293.92 pg/mL and 150.15 ± 105.34 pg/mL, having a very significant difference; vitamin E 8537.21 ± 6299.74 unit and 700.61 ± 233.70 unit, having a very significant difference. Conclusion: There is a very significant difference between an-giogenic markers and antioxidant levels in pre-eclampsia and normotensive pregnancies.