Article citationsMore>>
Gao, C., Liu, T., Dang, Y., Yu, Z., Wang, W., Guo, J., Zhang, X., He, G., Zheng, H., Yin, Y. and Kong, X. (2014) pH/Redox Responsive Core Cross-Linked Nanoparticles from Thiolated Carboxymethyl Chitosan for in Vitro Release Study of Methotrexate. Carbohydrate Polymer, 111, 964-970.
http://dx.doi.org/10.1016/j.carbpol.2014.05.012
has been cited by the following article:
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TITLE:
Inclusion-Interaction Assembly Strategy for Constructing pH/Redox Responsive Micelles for Controlled Release of 6-Mercaptopurine
AUTHORS:
Mingyuan Tan, Hua Zheng, Xueqiong Zhang, Zhiyan Yu, Zhao Ye, Liyan Shi, Kaikai Ding
KEYWORDS:
Chitosan, Cyclodextrin, 6-Mercaptopurine, pH-Sensitive, Redox-Responsive, Controlled Release
JOURNAL NAME:
Materials Sciences and Applications,
Vol.6 No.7,
July
8,
2015
ABSTRACT: An inclusion-interaction assembly strategy was used to construct novel pH/redox responsive
core-shell micelles with hydrophobic drug as the core and hydrophilic polymer as the shell. At first,
a dimer of hydrophobic drug 6-mercaptopurine and a hydrophilic β-CD grafted carboxymethyl
chitosan were synthesized. Then, a novel amphiphilic inclusion complex was prepared with the
dimer being partially embedded into the cavity of β-CD moiety. It self-assembled into pH/redox
responsive core-shell micelles in distilled water. TEM confirmed that the micelles possessed a
spherical core-shell configuration with a mean size of about 160 nm. DLS showed that the micelles
were stable in aqueous solution. Their particle diameters altered with pH values as well as glutathione
(GSH) concentrations and respectively attained a maximum value at pH 6.0 and 20 mM GSH.
Release profiles of 6-mercaptopurine showed a low release rate (about 27 wt% after 48 h) in pH
7.4 medium with 10 μM GSH, and a marked increase (over 88 wt% after 48 h) in pH 5.0 medium
with 20 mM GSH. In vitro cytotoxicity test showed that the micelles had a dose-dependent toxicity
for HeLa cells, indicating a great potential for controlled release of 6-mercaptopurine in tumor cells.