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Antón-Tay, F., Huerto-Delgadillo, L., Ortega-Corona, B. and Benitez-King, G. (1993) Melatonin Antagonism to Calmoduline May Modulate Multiple Cellular Functions. In: Toiutou, Y., Arendt, J. and Pévet, P., Eds., Melatonin and the Pineal Gland—From Basic Science to Clinical Application, Elsevier Science Publishers, Amsterdam, 41-46.

has been cited by the following article:

• TITLE: Effect of the Melatonin on Morning Blood Pressure Surge and Norepinephrine Endovenous Infusion in Healthy Volunteers

  AUTHORS: Jaime Carranza-Madrigal, José Miguel Cervantes-Alfaro, Sonia María López-Correa

  KEYWORDS: Blood Pressure, Hypertension, Melatonin, Norepinephrine, Orthostatism

  JOURNAL NAME: International Journal of Clinical Medicine, Vol.6 No.7, July 3, 2015

  ABSTRACT: Melatonin, the pineal gland hormone, has been considered as a central hypotension factor. However their roles in the regulation of the human blood pressure and its possible use as antihyper-tensive drug have not been fully determined. The objective of this trial was to determine the effect of melatonin on blood pressure morning increase and a peripheral vasoconstriction challenge in healthy volunteers. Twelve healthy male volunteers were included in a prospective, comparative, randomized, crossover trial in which changes on blood pressure (BP) and heart rate (HR) after the first morning orthostatism and endovenous norepinephrine (NE) infusion were measured one hour after the administration of placebo (PL) or 10 mg of melatonin in double blind conditions. Melatonin blunted the effects of the first orthostatism on BP and HR. Melatonin also reduces the pressor effect of NA. One concludes that melatonin has central and peripheral hypotensive effects that support a potential role of this hormone in cardiovascular therapeutics.