TITLE:
Carbohydrate-Derived Organocatalysts for the Reduction of Imines with Trichlorosilane
AUTHORS:
Xin Ge, Chao Qian, Xinzhi Chen
KEYWORDS:
Carbohydrate, Organocatalyst, Reduction, Imine
JOURNAL NAME:
Journal of Materials Science and Chemical Engineering,
Vol.3 No.6,
June
12,
2015
ABSTRACT: The backbone of D-glucosamine hydrochloride
was fine-tuned and modified by protecting the hydroxyl groups. In order to
reduce imines with trichlorosilane, the carbohydrate-derived organocatalysts
were prepared and screened. Methyl-4,6-O-benzylidene-2-amino-2-deoxy-α-D-glucopyr
anoside was found as the best catalyst. The reduction was proceeded under CHCl3
as solvent at 40?C, affording 68% - 94% yield.