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Liu, Y., Pan, N., Ma, Y., Zhang, S., Guo, W., Li, H., Zhou, J., Liu, G. and Gao, M, (2013)Inhaled sevoflurane may promote progressionof amnestic mild cognitive impairment: A prospective,randomized parallel-group study. Am J Med Sci, 345, 355-360. http://dx.doi.org/10.1097/MAJ.0b013e31825a674d

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• TITLE: Spanish Version of Test MIS (*) with Delayed Memory Recall Normative Values and Results in a Population with Mild Cognitive Impairment

  AUTHORS: Labos Edith, Trojanowski Sofía, Seinhart Daniel, Schapira Marcelo, Renato Alejandro

  KEYWORDS: Amnestic Mild Cognitive Impairment, Memory Test, Delayed Recall

  JOURNAL NAME: Advances in Alzheimer's Disease, Vol.4 No.2, June 30, 2015

  ABSTRACT: Background: Cognitive impairment becomes more common with ageing and may benefit from intervention. In a Spanish speaking population, detection of cognitive impairment by a general practitioner in Primary Care can be a problem, as many of the standard tests target English speaking populations. The Memory Impairment Screen (MIS-A) is a validated test using English words to detect Alzheimer’s Disease (AD) and other dementias. We have modified this test to suit a Spanish speaking population and added a new component, delayed recall. We have called our new test the Memory Impairment Screen with Delayed Recall (MIS-D). Objectives: 1) To test a Spanish version of MIS-A and MIS-D. 2) To assess the discriminative validity of MIS-D as a screening tool for the amnestic variant of Mild Cognitive Impairment (aMCI) in a group of Spanish speaking people aged 65 years old and over. Methods: A case-control study of a cohort of 739 native Spanish speaking residents of Buenos Aires aged 65 years old and over, of whom 436 were healthy controls and 303 had a diagnosis of aMCI. Measurements: Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NVP) were estimated for MIS-D and MIS-A. Results: Normative values for MIS-A and MIS-D were obtained from the control population. Both age and education significantly affected these values (p