TITLE:
Scalp Psoriasis: Systematic Review Comparing Topical Treatments and Placebo
AUTHORS:
Regina Jales, Sérgio Hirata, Álvaro Attalah, Danúbia Sá-Caputo, Adriano Arnóbio, Éric Heleno Frederico, Mario Bernardo-Filho, Humberto Saconato
KEYWORDS:
Scalp Psoriasis, Topical Treatments, Placebo, Topical Corticosteroids
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.5 No.2,
June
29,
2015
ABSTRACT: Patients with scalp psoriasis suffered from a lower quality of life
relating to the highly visible site of their psoriatic lesions. In consequence
this fact stimulates investigations involving treatments of this dermatologic
disease. The aim of this review is to evaluate the topical treatments for scalp
psoriasis compared with placebos. Methods: A systematic review was performed
using searches in the database LILACS, MEDLINE, Cochrane Library, and Embase.
As selection criteria were chosen eligible publications involving randomized
controlled trials, patients with scalp psoriasis diagnosed clinically or by
biopsy, interventions with topical treatments for scalp psoriasis compared with
placebo. Outcome related to the reduction in severity of psoriasis of the
scalp, assessed by physicians and patients, and assessment of adverse effects
that required discontinuation of treatment. The results have shown that the
patients were aged 12 to 97 years, including 3441 patients. Ten of the fifteen
studies included reported gender data. Patients were mostly female. Twelve
studies were about psoriasis’s severity. These studies in which the severity
has been described, the classification of severity was mild (0 study), mild to
moderate (1 study), moderate to severe (11 studies) and severe (0 study). In
conclusion, topical corticosteroids, calcipotriol, ciclopirox olamine and
associations between them are effective in the treatment of scalp psoriasis.
Clobetasol propionate (0.05%) was the most effective active ingredient in
several vehicles in the induction treatment of scalp psoriasis.