TITLE:
Neonatal Graves’ Disease and Cholestatic Jaundice: Case Series and Review of the Literature
AUTHORS:
Osama Almadhoun, Teresa Rivera-Penera, Lauren Lipeski
KEYWORDS:
Neonate, Graves’ Disease, Thyrotoxicosis, Hyperthyroidism, Cholestasis, Hepatitis, Jaundice, Conjugated Hyperbilirubinemia
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.5 No.2,
June
29,
2015
ABSTRACT: Cholestatic jaundice and
elevated liver enzymes are uncommon, but recognized, manifestations of neonatal
thyrotoxicosis. Current guidelines for evaluation of cholestatic jaundice and
reviews in Neonatology literature do not discuss hyperthyroidism in the
differential diagnosis of cholestatic jaundice. We report two cases of neonatal
thyrotoxicosis secondary to neonatal Graves’ disease that presented with
cholestatic jaundice and elevated liver enzymes at birth. Early recognition of
thyrotoxicosis as a cause of the hepatic disease in the neonate is crucial to
prevent unnecessary diagnostic procedures and to initiate timely treatment.