TITLE:
The Importance of Prolactin Levels in Patients Treated with Cabergoline for the Prevention of OHSS: Is Cabergoline Really Effective in Patients with High Risk of OHSS?
AUTHORS:
Serkan Oral, Yaşam Kemal Akpak, Nilay Karaca, Kadir Savan
KEYWORDS:
Cabergoline, Ovarian Hyperstimulation Syndrome (OHSS), Prolactine Levels, In Vitro Fertilization (IVF), Vascular Endothelial Growth Factor (VEGF)
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.5 No.6,
June
23,
2015
ABSTRACT: Background: OHSS is a dangerous and potentially life-threatening
condition for which many researchers look for new ways to treat. Aim: To
determine the effectiveness of prophylactic cabergoline administration on
prolactine levels in patients with high risk for ovarian hyperstimulation
syndrome (OHSS). Material and Methods: 163 in
vitro fertilisation (IVF) patients with high risk for OHSS were enrolled in
the study. The criteria for inclusion were more than 15 oocytes retrieved at
oocyte pick up. A standard antagonist protocol was used for ovulation induction.
Cabergoline treatments (0.5 mg/day) were started on the day of oocyte retrieval
and continued for eight days. Prolactine levels were measured at the day of
oocyte retrieval and the 9th day after the oocyte retrieval. Results: Of the
163 patients, 26 (15.9%) had OHSS. Prolactine levels on the day of oocyte
retrieval were 44.22 ± 24.78 ng/mL and 37.6 ± 22.5 ng/mL in patients with OHSS
and without OHSS, respectively (P > 0.05). In contrary prolactine levels
were significantly higher in patients with OHSS patients (3.9 ± 5.07 ng/mL)
than in patients without OHSS (2.1 ± 2.92 ng/mL) at the 9th day after oocyte
retrieval (P