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C. S. Lin, W. Z. Sun, W. H. Chan, C. J. Lin, H. M. Yeh, M. S. Mok, (2004) Intravenous lidocaine and ephedrine, but not propofol, suppress fentanyl induced cough. Can J Anaesth, 51, 654-9.

has been cited by the following article:

• TITLE: No relationship between the incidence of fentanyl-induced cough and smoking

  AUTHORS: Boris Pokhis, Hans-Bernd Hopf

  KEYWORDS: Cough, fentanyl induced; smoking; fentanyl induced cough; cough; fentanyl;

  JOURNAL NAME: Health, Vol.1 No.3, December 1, 2009

  ABSTRACT: The purpose of the study was to investigate whether or not the incidence of cough after intra-venous fentanyl depends on the patient’s smoking state and the speed of injection. 530 ASA class I-III patients free of bronchial hyperreactivity and res-piratory tract infection undergoing general anes-thesia for elective surgery were randomized to 1.5 g.kg-1 fentanyl injected over 2, 5 or 10 sec or pla-cebo via a peripheral intravenous cannula. The endpoint was cough within 5 min after completion of injection. Statistical evaluation was performed by factorial ANOVA and chi-square-test. Assuming around 25% smokers in our patient population calculated patient sample size was 340 per group. The study was terminated for futility after enrol-ment of 530 patients since an interims analysis yielded an incidence of cough of 2 % both in smokers (n=174) and nonsmokers (n=356, p= 0,970), which was unrelated to the speed of injec-tion and not different from placebo.