TITLE:
The Regulation and Interactions of the Hypoxia Inducible Factor Pathway in Carcinogenesis and Potential Cancer Therapeutic Strategies
AUTHORS:
Niraj Shenoy, Makardhwaj Shrivastava, Vineeth Sukrithan, Dimitra Papaspyridi, Karine Darbinyan
KEYWORDS:
Hypoxia Inducible Factor (HIF), Cancer Therapy
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.6,
June
17,
2015
ABSTRACT: The Hypoxia Inducible factor (HIF) pathway is known to be constitutionally
active in various cancers and is the dominant pathway in some cancers such as
VHL mutant clear cell Renal cell carcinoma. HIF-1α and HIF-2α overexpression is known to be important for tumor cell proliferation, maintenance
of stemness and angiogenesis. There has been growing interest in therapeutic
strategies targeting the HIF pathway over the last decade. We review in this
section the role of hypoxia inducible factor pathway in carcinogenesis, its
crosstalk with other pathways and potential cancer therapeutic strategies
targeting the HIF pathway, its upstream regulators and downstream signaling.