TITLE:
Mycosis Fungoides in Iraqi Patients—Clinical, Histopathological and Immunohistochemical Study
AUTHORS:
Hayder R. Al-Hamamy, Khalifa E. Sharquie, Adil A. Noaimi, Waqas S. Abdulwahhab
KEYWORDS:
Mycosis Fungoides, T-Cell Lymphoma, Immunohistochemical Examination, TNMB Classification
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.5 No.2,
June
12,
2015
ABSTRACT: Background: Mycosis fungoides (MF) is
not an uncommon T-cell lymphoma in Iraqi population which is increasing over
years. There are many diagnostic techniques to confirm the diagnosis including
histopathological and immunohistochemical tests. Objectives: To evaluate all
cases of MF including clinical, histopathological and immunohistochemical tests
with CD markers. Patients and Methods: This clinical, histopathological,
immunohistochemical outpatient based study took place in the Department of
Dermatology, Baghdad Teaching Hospital, Medical City, Baghdad, Iraq during the
period from May 2012-September 2013. Twenty five patients with MF were included
in the present work. History was obtained from each patient regarding all
socio-demographic aspects related to the disease. Also, clinical evaluation was
carried out for all patients. Incisional biopsies for ordinary histopathology
and immunohistochemical tests were done. Then staging was carried out depending
on TNMB classification for all patients. Results: All cases of MF were
confirmed after clinical evaluation, histopathology and immunohistochemical
examination. Male to female ratio was 1.5:1. The mean age of onset at
presentation was 47.45 ± 16.9 years. Itching was found in 84% of cases. The
patch stage was seen in 36% patients. The hypopigmentaed MF was presented in
12% cases. The lower extremities were seen in 80%. Lymph node involvement as a
manifestation of the disease was seen in 44% cases. The histopathological
features of MF went parallel with the clinical stage of disease.
Immunohistochemical study aids in the diagnosis of patch and erythrodermic
stages. The most patients presented with stage IB (36%). Conclusion: MF seems
to be not uncommon problem in Iraqi population and is increasing over years.
The disease was diagnosed early commonly with patch stage (stage IB)
while hypopigmented MF was not a common variant when compared with neighboring
countries.